My dogs have been throwing up since then and I could not for the life of me figure out why. Again he has diarrhea and this month he seems agitated or nervous. Im so worried Ive lost him forever and hell never recover. $20.45 Trifexis Chewable Tablets for DogsRx Product Details Product Description Simparica Trio Chewable Tablets for Dogs works to prevent heartworms as well as treat lone star ticks, black-legged ticks, Gulf Coast ticks, American dog ticks, brown dog ticks, fleas, roundworms, and adult hookworms. He wasnt throwing up at all until he received this medication. Now we are out thousands of dollars when every event has been triggered by Simparica Trio. According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. So we went home with her on steroids and more antibiotics and denamrin for liver. We took him to a emergency Vet Hospital that pin pointed Simparica Trio as the main facture that triggered his controlled seizure episodes in having constant all day tremors & seizures hurting him to the point of making the decision to put him down or have him continue with the pain until it killed him. The next month on a sunny weekend, we have him his meds and took him on a walk with his basket muzzle. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. Do not give extra or double doses. I dont know what to do to get this out of their system?? I do know that she was a healthy and somewhat energetic 10 year old before the treatment. My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. Hopefully yours will be lucky and return to normal. He hasn't eaten since and grazes on grass like he is a goat. In January, he was boarded and the boarder asked us if he could possibly be blind. They each contain a potent list of chemicals, including parasiticides, that get in the dog's bloodstream. We are experiencing the same thing. He has no appetite. Our dog has not been given another dose. I need to tell my vet to switch! Any tips on how to flush it from her system ? After reading theses comments I started looking into SIMPARICA TRIO. Not even going to risk it . I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. I am so fortunate the neurologist printed me that paper and I'm so glad that we can discontinue this medication and hopefully see him return to the quality of life he deserves! Then suddenly dog has diarrhea and it lasted for several days. I am devastated. This medicine is making her shaky/tremor, anxious, and she is panting a ton. Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hoursincluding the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. I let him back in the bedroom yesterday all went well, then this morning I woke to him peeing in the floor again. In a wellcontrolled US field study consisting of 246 dogs administered SIMPARICA TRIO and 119 administered an active control, no dogs treated with SIMPARICA TRIO tested positive for heartworm disease. He is 80% its been 27 days since 2nd dose of Simparico.hoping we turned the corner! My vet never mentioned that puppies under 6months cannot be prescribed this medication. I am trying to remain confident that my poor girl will recover. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. The whole packet is going in the bin !! I dont like that my dog looks at me like he doesnt know who I am. If it was due to the Simparica, then it would expected to be resolved within a day or two. I found a warning from the FDA about the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. I should have kept with my gut feeling about any of these oral meds. My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. How is your dog doing at this time? My vet is aware of this and prescribed simparica. My 11 year old terrier mix has been weak, uncoordinated and pacing up and down the hallway most of the day, sometimes stopping and staring at the wall. Any response from the company? Just wondering? I sure hope he makes it! Hi Charlene, can you elaborate on agitated swallowing? Hello! He was a Shih Tzu. Did you do this yourself or let the vet? Snores like a big dog. Hi, Im having similar issues. Gave our pup of 10 years the Simparica Trio as suggested by our vet 1 week ago instead of the Simparica and Interceptor he had been on for 7 years with no problems. After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. This is terrible. Simparica Trio chewable tablets for dogs 44-88 lbs So you can imagine my worry now. Does anybody know how long this will last? MONEY!!. with 801 Deaths and 1728 Seizures. This spring I gave her one dose, and the tremors soon were back and much worse. This morning was the first morning he left water in his bowl. He seems back to his normal self and playing with his toys, but we will not continue the following doses! Our vet gave us this medication for our 8 week old Great Dane puppy. She also started drinking excessively, and peeing in the house. Does anyone know of anything we can give her to help get this out of her system? I just found these comments and I am feeling terrible. Hi Laura, How is you pup doing one after getting off simparica? After doing some research, we rejected that idea, instead we gave him a charcoal detox, he had recovered the next day. Youre an idiot then! None of our pets did they were healthy. Never happened before. I disagree. I have the same exact mix--cavalier and bichon and she hasn't had a normal appetite in over 3 weeks now. Although the mother that took the same had not shown any effects. You ask why they are giving this poison to our furbabies, it's easy. I started giving my aussie shepherd simparica at 4 months. If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. I will post an update 7 days later. Some dogs also experience a temporary loss of appetite and may not eat their food at their usual meal times. He has been on just Simparica with no problems. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. I don't want another animal harmed by this stuff, one animal is one to many. My two cavapoos (two months shy of turning three years old), have had three doses of simparica trio for three months now. I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. The vet has not been able to diagnose a cause. Is the added expense worth the trouble to insure your beloved pet? Heres what you need to know about why cats purr and what your cat may be telling you when her motor is running. Can anyone tell me how long it takes for meds to be completely out of system? She went on 2 antibiotics, and medicated baths twice a week. His blood work came back normal but the vet called me to ask if his simparica somehow coincided with time of the seizures. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. I just hope and pray she gets better. It still makes me sick to think about her last month we miss her so much. Vet thinks it may be Addision disease and wants to test for it. I wish I read about this particular product before giving it to my dog because now I'm worried he may get more symptoms. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. He has been eating the same organic GF food for the past several years. We received the first dose of this medication from our Vet! After reading all your entries, i'm thrilled i chose to take her off of it. Today is day three and she is a little better, with fewer episodes of tremor and more often able to walk without falling. Im still confused. Billy Boy is a 9 week old Daisy Dog. However a spinal tap of the fluid surrounding the spinal cord would be need to prove your dog indeed has spinal meningitis and then to treat for the specific bacterium or viral causes. And then when we finally stop for the evening - she crashes. Advised her to put a big note on our account that she is never to have this again. Eat grass and vomit. Use a collar or topical if you need to. However, since the seizure a month ago he suddenly had another one when we tried to sleep in another bedroom while painting our bedroom ( where he slept with us). I am going to try stopping the medication for a month to see if things improve. (Ours never did, she died 4 months later.) My precious rescue has been sick twice, currently on her second episode. I will have to keep an eye out on her. He is stumbling, not able to stand on tile or go in and out of house without tripping on steps. The vet said not to give it. Thank you all so much for this thread and giving me hope. I will never give another dose to him! I switched all three of my dogs to simparica trio and ironically my one that is a simi feral h/w+ hound disappeared. For 5 years I have resisted my veterinarians suggestions for oral flea meds. Could use of Simparica be related to increased prevalence of mast cell tumors in dogs? Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. It is like night and day compared to her regular personality or demeanor. Unlike Bravecto, Simparica hasn't been tested on pregnant, lactating, or breeding dogs.

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