. * In fact, its antioxidant activity is 10 times higher than beta-carotene3, earning it titles like "King of Carotenoids" and "super antioxidant molecule" by researchers.*. This ad is displayed using third party content and we do not control its accessibility features. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. View abstract. Mercke, Odeberg J., Lignell, A., Pettersson, A., and Hoglund, P. Oral bioavailability of the antioxidant astaxanthin in humans is enhanced by incorporation of lipid based formulations. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Some of the top sources of astaxanthin include haematococcus pluvialis and the yeasts phaffia rhodozyma and xanthophyllomyces dendrorhous. Remember the free radicals we discussed above that can damage cells? Iwamoto, T., Hosoda, K., Hirano, R., Kurata, H., Matsumoto, A., Miki, W., Kamiyama, M., Itakura, H., Yamamoto, S., and Kondo, K. Inhibition of low-density lipoprotein oxidation by astaxanthin. Bioorg.Med Chem 8-15-2006;14(16):5451-5458. 2005 - 2023 WebMD LLC, an Internet Brands company. verified buyer of cellular beauty+. Want to boost your work out even more? Nutrients. Future.Cardiol 2009;5(4):333-342. Side effects of astaxanthin may include increased.Although studies in humans are limited, there are numerous astaxanthin benefits and side effects to consider that support biological functions. Well, astaxanthin makes foods red. 2015;54(2):301-7. J Sports Med Phys Fitness. Manabe, E., Handa, O., Naito, Y., Mizushima, K., Akagiri, S., Adachi, S., Takagi, T., Kokura, S., Maoka, T., and Yoshikawa, T. Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. Select a condition to view a list of vitamins. FASEB J 2009;23(6):1958-1968. Gharaei R, Alyasin A, Mahdavinezhad F, Samadian E, Ashrafnezhad Z, Amidi F. Randomized controlled trial of astaxanthin impacts on antioxidant status and assisted reproductive technology outcomes in women with polycystic ovarian syndrome. Med Sci Sports Exerc. Eur J Pharm Biopharm. This can happen during a heart attack. View abstract. Oxidative stress has been found to have a negative impact on kidney health. Research shows that it may be able to help improve brain, skin and heart health, support better vision, boost male fertility, increase endurance and reduce inflammation. *, Astaxanthin, like other carotenoids, can contribute to healthy peepers. Over time, astaxanthin can cause a variety of positive "side effects." Yamashita E. The effect of a dietary supplement containing astaxanthin on skin condition. According to a review out of Australia, there have been at least eight clinical studies measuring the effects of astaxanthin that have shown that astaxanthin supplementation may lower markers of both inflammation and oxidative stress. Mahmoud, F. F., Haines, D. D., Abul, H. T., Abal, A. T., Onadeko, B. O., and Wise, J. Nutr Res. Most of the studies looking at the benefits of astaxanthin as a dietary supplement used 6 to 8 mg per day. *, As astaxanthin supports the heart, it may also benefit the brain. There has been a lot of study on how astaxanthin can affect endurance, as well as fatigue levels after exercise. Minimizing your stress levels, getting in plenty of physical activity and cutting out ultra-processed foods are also key factors to keep your heart in tip-top shape. Arch Ophthalmol 1999;117:412-3. 2018;10(3). J Cell Biochem 4-15-2008;103(6):1925-1937. . * And a 2020 study found that due to its antioxidant properties, astaxanthin may support overall cardiovascular health . At this point, you may be wondering: How much astaxanthin should I take?. Astaxanthin is a powerful antioxidant that may help protect cells from damage from oxidative stress. The greatest attribute of astaxanthin is that it's both a powerful antioxidant and anti-inflammatory. Learn how to use astaxanthin to support your health goals. Eur J Nutr 2010;49(2):119-126. *) After all, it's not a competition. Phytomedicine. View abstract. The potential for astaxanthin to support hormones is present in early stages of animal studies. Omega-six fats promote inflammation, and omega-3 fats are anti-inflammatory. In some countries in Europe, SAMe is a prescription drug. Suganuma, K., Nakajima, H., Ohtsuki, M., and Imokawa, G. Astaxanthin attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts. Nir, Y., Spiller, G., and Multz, C. Effect of an astaxanthin containing product on rheumatoid arthritis. Coral-Hinostroza, G. N., Ytrestoyl, T., Ruyter, B., and Bjerkeng, B. View abstract. Fassett, R. G., Healy, H., Driver, R., Robertson, I. K., Geraghty, D. P., Sharman, J. E., and Coombes, J. S. Astaxanthin vs placebo on arterial stiffness, oxidative stress and inflammation in renal transplant patients (Xanthin): a randomised controlled trial. View abstract. As a supplement, some have reported mild side effects, though it is safe to take for your well-being in moderate doses. The U.S. Food and Drug Administration (FDA) does regulate dietary supplements; however, it treats them like foods rather than medications. 2000;7(4):216-222. Astaxanthin biochemical properties website. It has an exceptionally unique chemical makeup, allowing it to neutralize free radicals at a higher rate than other carotenoids4. One double-blind, placebo-controlled study showed that astaxanthin was the important variable that significantly improved wrinkles in 66 participants. Miyashita, K. Function of marine carotenoids. As weve discussed, astaxanthin is an antioxidant that protects against oxidative stress. View abstract. It also interacts with herbs, including saw palmetto, black cohosh and vitex. But as always, we recommend checking with your doctor before taking a supplement, astaxanthin or otherwise. Lee, D. H., Kim, C. S., and Lee, Y. J. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. With astaxanthin, the danger comes from isolating the stuff, packing it into a pill, and then telling people it will lower their cholesterol and blood pressure. 2007;57:26-30. Astaxathin, a carotenoid without vitamin A activity, augments antibody responses in cultures including T-helper cell clones and suboptimal doses of antigen. Arch.Toxicol. It's also a more economical approach, and you receive the astaxanthin benefits minus the potential contaminants from large quantities of fish (e.g., heavy metals). We currently have no information for ASTAXANTHIN overview. Other natural food sources of astaxanthin include shrimp, crayfish, krill, trout, yeast and algae. Astaxanthin has shown the highest oxygen radical absorbance capacity (ORAC), many magnitudes higher than other common antioxidants such as -tocopherol, -carotene, -carotene, lutein and lycopene. View abstract. * According to Kelley, this can also lower oxidative stress in the body overall, which will contribute to heart-health benefits. 6,245,818). Consider the following potential side effects: Considering these side effects were noted when taken in excess, let's talk dosage; the appropriate dosage for supplements is at least 3 milligrams per day, according to research. Astaxanthin may reduce the growth of H. pylori bacteria, which cause peptic ulcers. eat, so a supplement is way more practical. View abstract. Arch Ophthalmol 2008;126(10):1396-1403. Takemoto M, Yamaga M, Furuichi Y, Yokote K. Astaxanthin improves non-alcoholic fatty liver disease in Werner Syndrome with diabetes mellitus. Res PT, et al. Hussein, G., Sankawa, U., Goto, H., Matsumoto, K., and Watanabe, H. Astaxanthin, a carotenoid with potential in human health and nutrition. Leung LY, Chan SM, Tam HL, Wong ES. Imai A, Oda Y, Ito N, Seki S, Nakagawa K, Miyazawa T, Ueda F. Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study. The possible physiological effects of astaxanthin include: protecting the retina, improving eye fatigue, enhancing mitochondrial function, promoting the use of fat as an energy source, improving exercise function, beautifying the skin, controlling arteriosclerosis, and suppressing hypertension. Astaxanthin is a type of carotenoid found naturally in wild-caught salmon and other seafoods and green algae. Research suggests that astaxanthin may support healthy blood pressure levels already within normal range. Although studies in humans are limited, there are numerous astaxanthin benefits and side effects to consider that support biological functions. Chitchumroonchokchai, C., Bomser, J. In one 2016 animal study, for example, supplementation with astaxanthin increased the formation of new brain cells and enhanced spatial memory in mice. Cicero, AF, Rovati LC, and Setnikar I. Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. Case in point: According to a 2019 scientific article, it's been used as a supplement for more than two decades, and there are no documented negative side effects to date. Appl Microbiol Biotechnol 1997;48:351-6. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Its also responsible for providing that perfect pink color you might notice when picking out a fresh slab of salmon. With astaxanthin to help support skin hydration, elasticity, and smoothness. neutralize free radicals at a higher rate than other carotenoids, no documented negative side effects to date, extremely high and chronic intake of beta-carotene, skin inflammatory pathways and photoaging, shown to improve natural hydration levels in the eyes, https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/carotenoids, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946307/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917265/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5946307/, https://www.ncbi.nlm.nih.gov/books/NBK534878/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946307/table/nutrients-10-00522-t001/, https://pubmed.ncbi.nlm.nih.gov/22428137/, https://www.sciencedirect.com/science/article/pii/S1756464621005090?via%3Dihub, https://www.cdc.gov/heartdisease/brain_health.htm, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705074/, https://www.sciencedirect.com/science/article/abs/pii/S0014483520303729?via%3Dihub, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997915/. Comp Biochem Physiol C.Toxicol Pharmacol 2004;139(1-3):99-110. Wang, H. Q., Sun, X. Br J Nutr 2007;98(1):38-44. All rights reserved. However, further research in humans is needed to understand how astaxanthin may affect inflammation and disease in humans. View abstract. Despite the above recommendations . Astaxanthin is a carotenoid, a chemical found naturally in certain plants and animals. As a result, it could keep testosterone from changing into the hormone DHT in the body.Read user ratings and reviews for ASTAXANTHIN on WebMD . Miki, W., Hosoda, K., Kondo, K, and Itakura, H. Astaxanthin-containing drink. Fatty acid balance is also very important. Jyonouchi H, Sun S, Tomita Y, et al. It isn't associated with negative or long-lasting side effects. Ma B, Lu J, Kang T, Zhu M, Xiong K, Wang J. Astaxanthin supplementation mildly reduced oxidative stress and inflammation biomarkers: a systematic review and meta-analysis of randomized controlled trials. Cancer Lett. You know how the pigment beta-carotene makes carrots orange? Some men take saw palmetto so their body's level of dihydrotestosterone decreases and the level of testosterone increases. It may also play a role in eye and brain health. The kidneys filter your blood and remove wastes. View abstract. Astaxanthin is pronounced asta (like pasta) zan-thin. Some of the most commonly reported astaxanthin side effects include: Additionally, because research is limited on the safety of astaxanthin supplements in women who are pregnant or breastfeeding, its best to stay on the safe side and stick to food sources to get your daily dose. Astaxanthin | Perry Krichmar, MD If you are thinking about starting any new dietary supplement, its always a good idea to review the potential negative side effects it could cause. View abstract. 8-1-2003;307(3):704-712. Youre Not Alone, Pesticide in Produce: See the Latest Dirty Dozen, Having A-Fib Might Raise Odds for Dementia, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. 2002;21:489. And it may stimulate the immune system. Eye problems like macular degeneration and cataracts are common concerns associated with aging. 2002;30(1):73-84. Z Angew Chem 1938; 51: 465-466. View abstract. It can also be found in supplement form and is also approved for use as a food coloring in animal and fish feed. Astaxanthin is no exception a randomized, controlled trial published in 2012, involving 96 subjects, reported a significant improvement in cognition after being supplemented with the antioxidant for 12 weeks. Side effects of astaxanthin may include increased bowel movements and red stool color. Additional research and clinical trials are needed for conclusive results relating to hormones. 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To consider that support biological functions safe to take for your well-being in moderate doses and omega-3 are! Inflammation and disease in Werner Syndrome with diabetes mellitus astaxanthin supports the heart, it 's not competition!, K, and Bjerkeng, B the potential for astaxanthin to help support skin hydration, elasticity, Multz. ):99-110 2005 - 2023 WebMD LLC, an Internet Brands company, some have reported side! And disease in humans is needed to understand how astaxanthin can affect endurance, as well as fatigue levels exercise! Has been a lot of study on how astaxanthin may affect inflammation and disease humans... Eur J Nutr 2007 ; 98 ( 1 ):38-44 clones and suboptimal doses of antigen supplement way... Europe, SAMe is a type of carotenoid found naturally in certain plants and.... Affect endurance, as well as fatigue levels after exercise inflammation and disease in Werner Syndrome with mellitus... 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